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Extravascular injection might bring about community tissue problems with subsequent necrosis; consequences of intraarterial injection might vary from transient discomfort to gangrene of the limb. Any complaint of agony in the limb warrants halting the injection.The harmful dose of barbiturates may differ considerably. Barbiturate intoxication may v
Phenytoin, Sodium Valproate, Valproic Acid. The impact of barbiturates over the metabolism of phenytoin appears to get variable. Some investigators report an accelerating result, whereas Other folks report no result. Because the influence of barbiturates about the metabolism of phenytoin is not predictable, phenytoin and barbiturate blood levels ou